• 专利附录
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    • 专利摘要:
    device for removing and extracting removable material such as deposits from within hollow bodies, in particular for removing and extracting thrombosis emboli from blood vessels or the like, reducing catheter, and method for aspirating, fragmenting and extracting removable material such as deposits from within The invention relates to a device and method for aspirating, fragmenting and extracting removable material from hollow bodies, in particular for aspirating, fragmenting and extracting thrombi and emboli from blood vessels. For this purpose, the wire guide (11) is inserted into the hollow body (1) through an opening. material is removed by means of a reducing catheter (3) having a working head (6) comprising a stator (8) and a rotor (9) where the rotor (9) is connected to a flexible feed screw (1) surrounding the wire guide (11). the stator (8) has a side inlet opening (8a) over the circumference. The inlet opening (8a) in the stator (8) is formed by two circular holes arranged axially in succession with respect to the longitudinal axis of the dissolution catheter (3). material is forced into the inlet openings (8a), and the aspirated and / or detached probes and plungers (2) are sheared and / or fragmented between the peripheral edges of the stator inlet openings (8a) and of the rotor (9). a flexible sleeve (7) surrounding the feed screw (1) and connected to the stator (8) is used to discharge ablated material, and / or detached probes and plunger fragments. Before inserting the reducing catheter (3), a sheath catheter (4) is inserted into the hollow body (1) until it is positioned in front of the material to be removed. The cross-section of the hollow body (1) is then at least partially obstructed by the sheath catheter (4), thus preventing detached probes or plunger fragments from being accidentally dragged.
    公开号:BR112012004322B1
    申请号:R112012004322-6
    申请日:2010-08-25
    公开日:2019-11-05
    发明作者:Straub Immanuel；Heller Mathias
    申请人:Straub Medical Ag；
    IPC主号:
    专利说明:

    “DEVICE FOR REMOVING AND EXTRACTING REMOVABLE MATERIAL, SUCH AS DEPOSITS WITHIN HOLLOW BODIES, IN PARTICULAR TO REMOVE AND EXTRACT THRUMBLE AND BLOOD VESSELS AND PISTOLS, AND REDUCING CATHETER” [0001] the invention refers to a device and to refer to a device for extracting removable material, such as deposits within hollow bodies, in particular to remove and extract thrombi and emboli from blood vessels, said device comprising a reducing catheter that can be inserted into a hollow body, and a sheath catheter that can likewise , be inserted into a hollow body, where the reducing catheter and the sheath catheter each have a proximal end and a distal end, the sheath catheter being connected, in its distal end region, to a terminal piece, radially deformable in the form of a funnel, which is made of liquid-permeable material and widens in its cross section, towards its free distal end and, and the reducing catheter comprises a work head and a flexible sleeve connected thereto, where the work head of the reduction catheter has an outside diameter that is smaller than the inside diameter of the enlarged end piece, for insertion in the region of the funnel-shaped end piece of the sheath catheter. The invention also relates to a reduction catheter for such a device, and a method for removing and extracting removable material from inside hollow bodies.
    [0002] Deposits, for example, in the form of thrombi and emboli in blood vessels reduce the sectional area of flow in hollow bodies, such as blood vessels, arteries and veins. This can lead to congestion or a complete blockage (emboli) of the blood vessel. The health consequences can cause circulation disorders or, in extreme cases, deficiency in the extremities or even in vital organs.
    Petition 870190078802, of 08/14/2019, p. 11/46 / 21 [0003] In particular, hollow bodies can also mean: by-passes, stents or similar, but also hollow organs, such as the bladder, kidneys, lungs, heart and uterus.
    [0004] A catheter, in particular, for removing fresh blood clots is known from WO-A-2005/084562, mentioned catheter having a working head comprising a stator and a rotor that rotates on it, and is connected to the screw food. The commercial name of this catheter is Aspirex ® (registered trademark of the applicant). The stator is provided, in its circumference, with at least one inlet opening. The deposits to be ablated are sucked into the stator through the inlet openings, as a result of the vacuum produced by the supply screw, the aforementioned deposits being fragmented in the stator, between this and the supply screw as a result of the shearing action, and finally being discharged by the feed screw. Particularly, in the case of non-homogeneous deposits, it may be that individual particles are dragged with the blood flow, and new congestions may develop in more distant places, where the lumen of the vessel is smaller.
    [0005] US-A-5,102,415 features a device for mechanically removing blood clots from veins and arteries. An external catheter is first inserted into the blood vessel through a wire guide until it is positioned in front of the thrombus. A sheath catheter is then inserted through the external catheter. The sheath catheter is provided with a radially expandable end piece at its distal end. When the sheath catheter is inserted into the external catheter, the end piece is reduced to the internal diameter of the external catheter. Once the end piece has been pushed through the external catheter, the end piece opens in the form of a funnel. An internal catheter is then inserted through the sheath catheter and through the thrombus. A miniature balloon is placed at the distal end of the internal catheter. Once
    Petition 870190078802, of 08/14/2019, p. 12/46 / 21 internal catheter has penetrated the thrombus to be removed from the blood vessel, the miniature balloon is inflated. When removing the internal catheter, the thrombus is then mechanically pulled into the funnel-shaped end piece. The thrombus is then removed from the blood vessel by extracting the external catheter together with the sheath catheter and the internal catheter. This method has the disadvantage that any thrombus residue that remains adhered to the vessel wall can again form obstacles to flow and / or can later be entrained. The waste that is taken away can cause new blocks in the distal and narrow narrow blood vessels.
    [0006] A device for removing blood clots is known from US-B-6,454,775, and comprises a flexible catheter and a motor-driven steering unit. A radially expandable work head comprising flexible wires is placed at the distal end of the catheter. The deposits will be detached and removed by the rotation of the work head.
    [0007] In figure 9, US-B-6,454,775 shows a second catheter that is inserted into the blocked blood vessel on the opposite side. This second catheter is provided with a funnel-shaped end piece radially expanded at its distal end. The deposits detached through the working head, and dragged with the blood flow, are entirely captured by the funnel-shaped end piece, and then sucked up by the steering unit.
    [0008] Removing thrombi via this system is relatively complex since the deposits removed consist of larger and smaller fragments that tend to stick together but cannot be comminuted, and therefore the remaining particles in the blood can float. the same. This leads to the formation of accumulations and blockage of the venous system.
    [0009] A device for removing and extracting deposits from inside hollow bodies is known from US-B-6,579,298 and comprises a reducing catheter that can be inserted into the hollow body, and a sheath catheter
    Petition 870190078802, of 08/14/2019, p. 13/46 / 21 which can likewise be inserted into the same hollow body. The reducing catheter and the sheath catheter each have a proximal end and a distal end. The sheath catheter is connected at its distal end to a funnel-shaped radially deformable end piece, which is made of liquid-permeable material and expands in its cross section, towards its free distal end. The reducing catheter has a work head and a flexible sleeve connected to it, where the work head of the reduction catheter has an external diameter smaller than the internal diameter of the enlarged end piece, for insertion in the region of the end piece sheath catheter funnel. The working head of the reducing catheter is formed as a cutter.
    [00010] To remove and extract deposits from inside hollow bodies, the reducing catheter and the sheath catheter are inserted into the hollow body simultaneously in the device according to US-B-6,579,298, until they are positioned in front of the material to be removed. The funnel-shaped end piece of the sheath catheter is then expanded, by means of which the hollow body is closed, at least in part. The deposit is then reduced in the hollow body by means of the cutter, the material reduced by the cutter being sucked through the flexible sleeve.
    [00011] The cutter simply comminutes the deposits into pieces of indefinite sizes. Pieces of material to be removed can thus accumulate, which can block the flexible sleeve and thereby remove deposits.
    [00012] The object of the invention is to create a device that, in particular, allows for rapid and reliable removal of blood vessel thrombi, but which can also reliably perform ablation and remove solid material from any other hollow bodies, without having parts of solid bodies dispersed around the working area. Another objective of the invention is to create a method that allows a simple and reliable removal, in particular, of thrombi of
    Petition 870190078802, of 08/14/2019, p. 14/46 / 21 blood vessels.
    [00013] According to the invention, this is achieved with the device, once the working head of the reducing catheter has a stator in the form of a sleeve and a rotor, which is arranged centrally in it, and is rotatable with respect to the stator. The mentioned stator being provided, on its circumference, with at least one lateral entrance opening, and said rotor being connected to a steering unit and feed screw, or being formed in one piece, with at least one lateral entrance opening in the stator being formed with at least two circular holes, arranged axially in succession with reference to the longitudinal axis of the reducing catheter.
    [00014] The production of substantially circular holes is particularly easy, using conventional tools such as drills, milling cutters, etc. Circular holes can also be produced by drilling, erosion or water jet cutting, or by any other means. The edges that define the holes form sharp edges, in which the aspirated material is comminuted. Two cutting edges, arranged in an arc seen from the longitudinal direction of the work head, are formed in each hole. Consequently, four cutting edges are provided with two holes, six cutting edges are provided with three holes, etc. As a result of this design with at least one side inlet opening, the working head of the reducing catheter cannot be caught by the sheath catheter during the reduction process. At the same time, the cutting edges of the inlet opening ensure a cutting function of the reducing catheter so that the deposits reduced by the reducing catheter are fragmented and comminuted so that a high reduction capacity is provided without the risk of the flexible sleeve becoming blocked when the fragmented material from the deposits is sucked through the flexible sleeve.
    [00015] Due to the combination, according to the invention, with the catheter
    Petition 870190078802, of 08/14/2019, p. 15/46 / 21 of cut, the risk of individual thrombus particles being dragged by blood circulation or flow to more distant and sometimes inaccessible locations, can be virtually excluded. Such particles trapped in the funnel-shaped end piece of the cutting catheter can then also be removed from the end piece via the reducing catheter itself. [00016] Although the cutting catheter end piece previously had the function of capturing and storing it safely, it is now simply used as a barrier against entrainment of particles, due to the new combination with the reducing catheter. The cutting catheter end piece is simply used to increase reliability so to speak, and it is no longer used to actually discharge the material to be removed. A completely new use for the end piece, which is known per se, and an increased and more reliable treatment of vessel occlusions as a whole, is thus provided. The cooperation of the two catheters, therefore, achieves optimal results when removing material from hollow bodies.
    [00017] In one embodiment of the device, the cutting catheter has a central duct, through which the reducing catheter can be inserted until the working head of the reducing catheter, in the reducing state, protrudes as far as the funnel-shaped end piece region. With this device, the sheath catheter and the reducing catheter are thus inserted into the hollow body on the same side, preferably against blood flow. Similarly, the reducing catheter initially removes the thrombus by advancing the reducing catheter. With subsequent retraction, the funnel-shaped end piece can be released via the reducing catheter, and the particles trapped in it can be removed. The advantage of this project is that the patient will only have to be opened in one place.
    [00018] Of course, with this design and the use of this invention, the reducing catheter can also be positioned relatively far away in two narrow vessels. The inner diameter of the vessel simply defines the diameter
    Petition 870190078802, of 08/14/2019, p. 16/46 / 21 of the reducing catheter, which, however, can be formed relatively small.
    [00019] A particular expedient, in one embodiment, consists of the circumferences of the holes overlapping. For example, with two holes having overlapping circumferences, an entrance opening with an approximate shape of 8 is formed. This shape is advantageous for cooperation with the funnel-shaped end piece, since the sheath catheter end piece thus, it is largely prevented from being captured by the working head of the reducing catheter.
    [00020] The holes are advantageously interconnected by a slot with a path in axial direction, and arranged substantially centralized with respect to the holes. This gap prevents the formation of an acute tooth that can be formed with holes that have overlapping circumferences. In addition, other cutting edges are formed by the crack, mentioned edges cooperate advantageously during the fragmentation or comminution of the material aspirated by the reducing catheter.
    [00021] The slot conveniently extends towards the proximal end of the reducing catheter beyond the holes. A duct, which is narrower than the hole diameters, is thus formed at the extent of the holes. Particularly, hard parts of a thrombus, which could not be sheared in the region of the holes, are sucked into this duct and are sheared, at most, at the proximal end of the duct. The cutting edges created additionally by the formation of this crack, advantageously help the fragmentation of the material aspirated by the reducing catheter. It is again emphasized here that the discharge, through the flexible sleeve of the reducing catheter, is advantageously ensured by sufficient comminution or fragmentation of reduced material and aspirated by the work head, and those complications, which may occur during a surgical procedure, such as
    Petition 870190078802, of 08/14/2019, p. 17/46 / 21 result of a blocked suction duct, are greatly excluded. [00022] Two diametrically opposite side inlet openings are advantageously provided in the stator of the reducing catheter. The two diametrically opposed inlet openings provide a uniform distribution of force during the reduction process, and also provide a greater reduction capacity with a corresponding capacity for the feed screw. In addition, a multiplicity of cutting edges is available in the stator to ensure sufficient fragmentation of the material aspirated by the work head. The mutually opposite side inlet openings are particularly advantageous, arranged as mirror images, thereby ensuring a more uniform distribution of force during the reduction process and, therefore, an increased reduction capacity.
    [00023] The size of the thrombi to be removed from a blood vessel can vary widely. It has therefore been proven to be advantageous when the outside diameter of the working head stator is graduated so that it becomes tapered towards its distal end. With the tapered section at the distal end of the stator, a type of “central hole” is first produced in the thrombi and then is drilled by the subsequent enlarged diameter section. This new form of stator allows for a very high reduction capacity and thus leads to short treatment periods for patients.
    [00024] The end piece, particularly and conveniently, has a screen structure or lattice structure in the expanded state of it. For example, this structure can exist in the form of a fabric made of a textile or metal material. As already mentioned, the purpose of the end piece, in the form of a sheath catheter funnel, is to trap any particle of thrombus that has been dragged out of the blood flow. For this reason, a funnel-shaped end piece made of material
    Petition 870190078802, of 08/14/2019, p. 18/46 / 21 liquid permeable is preferred, whereby blood flow is only restricted, but not stopped completely, when the end piece is expanded.
    [00025] To insert the sheath catheter in the hollow body, the end piece is advantageously tapered towards the outer diameter of the sheath catheter. If the end piece reached its position after insertion into the hollow body, the end piece expands again, with advantage, conically. The end piece can therefore advantageously be expanded in the form of an umbrella.
    [00026] With sufficient elasticity or solicitation of the material used for the end piece, it can unfold automatically as soon as it is positioned at the desired point. The end piece is advantageously radially expandable by means of an inflatable balloon, by means of a self-expanding mechanism or by means of the reducing catheter. These assistive means allow the end piece to unfold or expand, even if there is a high resistance against the unfolding of the end piece. Any technique that results in the positioning of the end piece being opened so that the vessel or hollow body (for example, a stent) is closed in a particle-impervious manner (impervious to non-liquids), can be used to form the end piece sheath catheter. In particular, self-expanding texture grids can be used for this purpose.
    [00027] The working head of the reducing catheter preferably has an additional rotor element that rotates relative to the stator. A reducing catheter of this type is known under the trade name Rotarex ® (applicant's brand) and makes it possible to break and reduce harder occlusions. The additional rotor element can be arranged on the internal face of the stator, for example, in order to preserve the hollow body walls, when occlusions are broken and reduced. Alternatively, the additional rotor element that rotates
    Petition 870190078802, of 08/14/2019, p. 19/46 / 21 in reference to the stator is arranged on the external surface of the stator. [00028] The edges of the perforations are preferably formed from sharp edges, thereby ensuring an improved fragmentation of the material aspirated by the reducing catheter. The cutting edges are advantageously formed by sharp edges, which are arranged on the stator of the work head facing the feed screw. The cutting edges can also have a structured course, for example, a wavy and / or zigzag course.
    [00029] The new stator shape of the reducing catheter can also advantageously be used independently of the sheath catheter, which is the reason for another invention to be considered in it.
    [00030] An advantageous method, according to the invention, for removing material from inside hollow bodies, in particular, to remove thrombi and emboli from blood vessels, also referred to as occlusion removal, is to insert at least one wire guide into the hollow body and, before the reducing catheter is inserted, insert a sheath catheter, which is designated according to the above-mentioned embodiments, along the inserted wire guide to the front of the material to be removed, and occluding the cross section of the hollow body by means of the sheath catheter, at least in part; the material to be removed being reduced by a reducing catheter, which is designated according to the aforementioned embodiments, thus aspirated and sucked through the flexible glove. This method allows the removal of deposit located in the hollow body, without parts of reduced material being deposited by blood flow in more distant places in the hollow body, which could lead to new constrictions or occlusions of the hollow body in these places.
    [00031] The sheath catheter is conveniently inserted, first into the hollow body until it is positioned in front of the material to be removed, the hollow body is closed, at least in part, by the end piece
    Petition 870190078802, of 08/14/2019, p. 20/46 / 21 which expands radially connected to the distal end of the sheath catheter. The reducing catheter is then inserted into the hollow body on the opposite side of the sheath catheter until it is positioned in front of the material to be removed, and the material to be removed is then aspirated into at least one inlet opening in the stator, by rotation of the feed screw, and it is fragmented and then extracted through the flexible sleeve. [00032] The sheath catheter is preferably inserted into the hollow body in the direction against blood flow. When the material to be removed is reduced by the reducing catheter, the detached material transported by the blood flow is captured and collected by the end piece of the sheath catheter. Once the deposit in the hollow body has been removed, the expanded end piece of the sheath catheter can be cleaned by means of the reducing catheter, which is, as it were, emptied of reduced deposit material collected by the end piece. The sheath catheter end piece is then advantageously retracted and the sheath catheter and reducing catheter are removed from the hollow body in opposite directions.
    [00033] In another method, the material of a filter already fixed, temporarily or permanently, in the hollow body is emptied by means of the reducing catheter. In known applications, a filter is positioned in the hollow body and closes the hollow body in a permeable to liquid, but impermeable to particles. This filter can be arranged in the hollow body temporarily, for example, before or during the surgical procedure, or permanently, that is to say for a relatively long period of time. In order to ensure the flow of blood through the filter, arranged temporarily or permanently in the hollow body, said filter must either be removed from where the material collected in this filter can spread through the hollow body and, therefore, through the blood flow during the process. removal, or be removed using a reducing catheter. In this case, the device according to the invention is used
    Petition 870190078802, of 08/14/2019, p. 21/46 / 21 with advantage. For example, the sheath catheter is advantageously advanced first against the blood flow or on the opposite side of the blood flow, until it faces the arranged filter, temporarily or permanently, in the hollow body, and the end piece of the sheath catheter it is expanded to close the hollow body, at least in part. The reducing catheter is then inserted into the hollow body from the other side and the filter fixed, temporarily or permanently, in the hollow body is removed. Any filter material, arranged temporarily or permanently, in the hollow body dragged by the blood flow is captured by the expanded end piece of the sheath catheter, and can likewise be removed from the hollow body, when the sheath catheter is removed from the hollow body.
    [00034] Another advantageous alternative method is to first again insert the sheath catheter into the hollow body until it is positioned in front of the material to be removed and close the hollow body, at least in part, with the radially expanded end piece. The reducing catheter is then inserted into the hollow body coaxially through the central duct, through the sheath catheter until it is positioned in front of the material to be removed, and the material to be removed is then aspirated into at least one inlet opening with the rotation of the feed screw, and it is fragmented, and then extracted through the flexible sleeve. In this method, the sheath catheter and the reducing catheter are preferably introduced into the hollow body and, therefore, into the body in the same location so that only an insertion opening, for example, in the patient's body, has to be created.
    [00035] A common wire guide is first and conveniently inserted into the hollow body, and then both the reducing catheter and the sheath catheter are inserted into the hollow body through a common wire guide, either together or staggered in time, from one side, or one opposite the other, this means two sides. The wire guide is first inserted into the body
    Petition 870190078802, of 08/14/2019, p. 22/46 / 21 hollow, for example, with the assistance of X-rays, which guides the sheath catheter and the reducing catheter during their insertions in the hollow body. The common wire guide ensures that the reducing catheter and the sheath catheter meet. The reducing catheter and the sheath catheter can, therefore, cooperate in the best way, avoiding the risk of leaving a blood vessel.
    [00036] In a step of an alternative method, a first wire guide for the sheath catheter is inserted into the hollow body, and a second wire guide for the reducing catheter is inserted into the hollow body in the opposite direction from the insertion of the first guide of wire. The first wire guide is then removed, at least in part, and the second wire guide is then inserted into the sheath catheter, at least through a region thereof, and the reducing catheter is then reliably inserted into the hollow body when along the second wire guide towards the sheath catheter. The wire guides normally used in such methods have a flexible tip that makes it easier to find the hollow body in question, for example, if there are branches. It is, therefore, sometimes difficult to insert the sheath catheter and / or the reducing catheter into the hollow body through this flexible tip of the wire guide. As a result of the insertion of the second wire guide in the sheath catheter, at least over a region of it, it is ensured, in another advantageous way, that the reducing catheter and the sheath catheter meet and that the reducing catheter and the catheter of sheaths can therefore cooperate with each other in the best way.
    [00037] The end piece connected to the proximal end of the sheath catheter is preferably radially expandable by means of an inflatable balloon, by means of a self-expanding mechanism, or by the reducing catheter, which ensures that the hollow body is closed, at least in part, by the expanded end piece.
    Petition 870190078802, of 08/14/2019, p. 23/46 / 21 [00038] The invention will be explained in greater detail with symbols and by means of examples based on drawings.
    [00039] The drawings will be described coherently and comprehensively. Like reference signs denote like components.
    [00040] In the drawings:
    [00041] Fig. 1 shows a blood vessel blocked by a thrombus with a reducing catheter and a sheath catheter, inserted in the hollow body in different directions, at the beginning of the treatment;
    [00042] Fig. 2 shows the blood vessel according to Fig. 1 after removal of the thrombus;
    [00043] Fig. 3 shows a variant of the method illustrated in Figs. 1 and 2;
    [00044] Fig. 4 shows an enlarged longitudinal section view of the reducing catheter that can be seen in Figs. from 1 to 3;
    [00045] Fig. 5 shows a longitudinal section view of a variant of the reducing catheter shown in Fig. 4;
    [00046] Fig. 6 to 10 show different embodiments of the stator arranged at the distal end of the reducing catheter, and [00047] Fig. 11 shows another variant of the method illustrated in Figs. 1 and 2. [00048] Figs. 1 to 3 show schematic views of a hollow body 1, for example, a vein or artery, in longitudinal section. A deposit, preventing blood circulation, is located in the hollow body 1. For example, this can be a thrombus 2 or an embolus, the material from which it must be removed in order for the blood circulation to function properly again, and for the organs of the body are sufficiently supplied with the necessary substances.
    [00049] A device for removing and extracting a thrombus 2 from inside the hollow body 1 is illustrated in each of Figs. 1 and 2. The device comprises a reducing catheter 3 which can be inserted into the hollow body 1, and a sheath catheter 4 which can likewise be inserted into the
    Petition 870190078802, of 08/14/2019, p. 24/46 / 21 same hollow body 1. The sheath catheter 4 has a proximal end 4a and a distal end 4b. The distal end 4b of the sheath catheter 4 is connected to a radially deformable funnel-shaped end piece 5 made of liquid-permeable material.
    [00050] The reducing catheter 3 likewise has a proximal end 3a and a distal end 3b. A working head 6 is located at the distal end 3b. The working head 6 is connected to a flexible tubular sleeve 7. The working head 6 of the reducing catheter 3 has an outside diameter that is smaller than the inside diameter of the expanded end piece 5, for insertion in the region of the shaped end piece funnel 5 of the sheath catheter 4. As will be described in detail below, together with Figs. 4 to 10, the working head 6 of the reducing catheter 3 has a glove-shaped stator 8, and a rotor 9 which is arranged centrally therein, and is rotatable with respect to the stator 8, mentioned stator 8 being provided, on its circumference, with at least one lateral entrance opening 8a.
    [00051] In the method illustrated in Figs. 1 and 2, a first wire guide 31 is first inserted into the hollow body 1 to approximately thrombus 2 (see the dashed end of the first wire guide 31). The sheath catheter 4 is then, in the same way, inserted into the hollow body 1 through the first wire guide 31 on the same side, and is advanced until it is immediately positioned in front of the thrombus 2 to be removed. During the insertion process, the diameter of the end piece 5 is compressed, for example, by a destructible sleeve. If the desired position of the end piece 5 of the sheath catheter 4 is reached, the sleeve is then removed and the end piece 5 can unfold in the shape of an umbrella as a result of its own elasticity. Alternatively, the end piece 5 is radially expanded by additional external tools, for example, by means of an inflatable balloon, by means of a self-expanding mechanism, or by the catheter
    Petition 870190078802, of 08/14/2019, p. 25/46 / 21 reducer. The hollow body 1 is closed, at least in part, by the end piece 5 of the sheath catheter 4. As a result of the liquid permeable material of the end piece 5, blood can, however, still flow through the hollow body 1. Only the solid components or particles contained in the blood flow are filtered through the end piece 5 of the sheath catheter 4.
    [00052] A second wire guide 32 is inserted into the hollow body 1 on the side of the thrombus 2, opposite the sheath catheter 4, or just after the sheath catheter 4 has been correctly positioned in the pre-defined position, or before the catheter sheath 4 has been positioned, and is advanced through thrombus 2. The first wire guide 31 is then slightly removed, and the second wire guide 32 is then further advanced so that the free end 33 of it penetrates the sheath catheter 4 over a region thereof. The reducing catheter 3 is then inserted into the hollow body 1 along the second wire guide 32, on the opposite side of the sheath catheter 4.
    [00053] As can be seen, in particular in Fig. 4, the working head 6 of the reducing catheter 3 comprises a glove-shaped stator 8 and a feed screw 10, which is coaxially mounted to it, and connected integrally or coupled to a rotor 9, thus acting as a feed screw. In the present example, the portion of the distal end of the feed screw 10 rotating in the stator 8 forms the rotor 9. The stator 8 is provided with at least one lateral inlet opening 8a and, at its distal end, has a closing section in towards the free end. The stator 8 is connected, at its proximal end, to a flexible tubular sleeve 7.
    [00054] As shown in Fig. 1, thrombus 2 is then reduced by the working head 6 of the reducing catheter 3. Parts of the thrombus 2 are removed through the inlet opening 8a of the stator 8 into the working head 6 as a result of a vacuum produced by the rotation of the
    Petition 870190078802, of 08/14/2019, p. 26/46 / 21 feed 10, and are sheared (fragmented or comminuted) at the edges of the inlet opening 8a by the relative rotation between rotor 9 and stator 8, and discharged through flexible sleeve 7, through the feed screw
    10. The sheath catheter 4 flexes continuously in its end piece 5 during the reduction process, so that the hollow body 1 is reliably occluded.
    [00055] Any components of thrombus 2 that come off and are not sucked by the working head 6 of the reducing catheter 3, components that are further transported by the blood stream or blood flow, are captured by the expanded funnel-shaped end piece 5, sheath catheter 4. Once the entire thrombus 2 has been removed using the reducing catheter 3, the funnel-shaped end piece 5 of the sheath catheter 4 can also be cleaned by further advancing the reducing catheter 3 , and emptied of the particles trapped in it. This can be seen clearly in Fig. 2. The second wire guide 32 can be removed slightly to release the end piece 5 of the sheath catheter 4, and therefore the working head 6 of the reducing catheter 3 is moved freely within the terminal part 5 of the sheath catheter 4. The reducing catheter 3 and the second wire guide 32, as well as the sheath catheter 4 and the first wire guide 31, are then extracted from the hollow body 1 in opposite directions and removed from there.
    [00056] In the method illustrated in Fig. 3, in contrast to the method according to the illustrations in Fig. 1 and 2, the reducing catheter 3 and the sheath catheter 4 are inserted into the hollow body 1, on the same side. The sheath catheter 4 is first inserted into the hollow body along a wire guide 11 previously inserted until it is positioned in front of the thrombus 2 to be removed. The funnel-shaped end piece 5 of the sheath catheter 4 is then radially expanded so that the hollow body 1 is closed, at least in part. Once the end piece 5 is
    Petition 870190078802, of 08/14/2019, p. 27/46 / 21 arranged in position, the reducing catheter 3 is inserted through the central duct 4c in the sheath catheter 4, and the reduction of thrombus 2 is initiated on this side. Any particles that come off and are dragged by the blood flow are captured by the funnel-shaped end piece 5 of the sheath catheter 4, similarly to the methods described together with Figs. 1 and 2. When the reducing catheter 3 is then removed via the sheath catheter 4, the funnel-shaped end piece 5 of the sheath catheter 4 can be cleaned and any particles located therein can be removed. With this method, the reducing catheter 3 and the sheath catheter 4 are guided by a common wire guide 11.
    [00057] In a variant, in which the reducing catheter is also used, at the same time, to expand the end piece of the sheath catheter, the said sheath catheter is formed, in the radially internal region, so that it is narrower than than the outside diameter of the reducing catheter. If the reducing catheter is then pushed forward with light pressure, it expands the end piece of the sheath catheter.
    [00058] In the method illustrated in Fig. 11, material 52 is removed from a filter 51, which is already arranged, temporarily or permanently, in the hollow body 1, by means of the device comprising a sheath catheter 4 and a reducing catheter 3 The method for positioning the sheath catheter 4, and arrangement of the reducing catheter 3, basically corresponds to the methods described together with Figs. 1 and 2.
    [00059] When the material located in the filter 51 is removed, any particles carried by the bloodstream are captured by the expanded end piece 5, of the sheath catheter 4.
    [00060] A variant of a working head 36 of a reducing catheter 3 is illustrated in Fig. 5. In addition to stator 38, working head 36 also comprises, in this case, an additional external rotor element 41. Stator 38 also has a plurality of inlet openings 38a that
    Petition 870190078802, of 08/14/2019, p. 28/46 / 21 are each formed by three circular holes 42, 43 and 44 arranged axially in succession with reference to the longitudinal axis of the reducing catheter
    3. The circumferences of holes 42, 43, and 44 overlap. As a result of the design of the holes 42, 43 and 44, each inlet opening 38a has six cutting edges, which are advantageously formed as cutting edges.
    [00061] In a variant not shown at this time, the additional rotor element 41 is provided on the inner face of stator 38.
    [00062] Figs. 6 to 10 show different ways of carrying out the stator.
    [00063] With stator 14 according to Fig. 6, two circular holes 15 and 16 are arranged axially in succession so that the circumferences of them overlap in part. This side entrance opening 14a thus has the shape of a figure at 8 and has four sharp edges.
    [00064] With the stator 17 which can be seen in Fig. 7, two holes 18 and 19 are likewise arranged axially in succession and form the side entrance opening 17a. In this case, however, the circumferences of the holes do not overlap. The two holes 18, 19 are interconnected by the slot 20 which extends in an axial direction.
    [00065] The stator 21 that can be seen in Fig. 8 differs from the embodiment according to Fig. 7, since a slot 24 extends axially beyond the two holes 22, 23 towards the proximal end. The slot 24 and the two holes 22,23 form the side entrance opening 21a. This slot 24 is particularly advantageous in the case of very hard and fibrous material undergoing ablation, since it provides good shear and, therefore, fragmentation of the aspirated material as a result of the additional cutting edges available.
    [00066] As stator 25, which can be seen in Fig. 9, shows two approximate and diametrically opposed entry openings 26, they can also be provided and arranged advantageously in a mirror image.
    Petition 870190078802, of 08/14/2019, p. 29/46 / 21 [00067] Stator 27, which can be seen in Fig. 10, differs from the embodiments illustrated in Figs. 5 to 9, since the diameter of the aforementioned stator is graduated towards its distal end. The reduced diameter of stator 27 at its distal end allows easier penetration of the reducing catheter 3 into the material to be removed.
    [00068] The ways of making the side entrance openings in the stator that can be seen in Figs. 5 to 10 are particularly convenient in cooperation with the funnel-shaped end piece 5 of the sheath catheter 4. The stator can thus be largely prevented from being captured or stuck in the material of the end piece 5.
    List of reference symbols
    1 hollow body 21 stator 2 thrombus 21st inlet opening 3 reducing catheter 22 hole 3rd proximal end of 3 23 hole 3b distal end of 3 24 slit 4 sheath catheter 25 stator 4th proximal end of 4 26 entrance opening 4b distal end of 4 27 stator 4c central duct of 4 28 step 5 terminal piece 29 hole 6 work head 30 crack 7 flexible glove 31 first wire guide 8 stator 32 second wire guide 8th inlet opening 33 32 free end 9 rotor 10 power screw 38 stator 11 wire guide 38a entrance opening
    Petition 870190078802, of 08/14/2019, p. 30/46 / 21
    3940 rotorpower screw 14 stator 41 rotor element 14th entrance opening 42 hole 15 hole 43 hole 16 hole17 stator 44 hole 17th entry opening 51 filter 18 hole19 hole20 slit 52 material
    Petition 870190078802, of 08/14/2019, p. 31/46 / 4
    权利要求:
    Claims (15)
    [1]
    1. Device for removing and extracting removable material, such as deposits from inside hollow bodies (1), in particular for removing and extracting thrombi (2) and blood vessel emboli or the like, said device comprising a reducing catheter (3) which can be inserted into the hollow body (1), and a sheath catheter (4) which can likewise be inserted into the aforementioned hollow body (1), the reducing catheter (3) and the sheath catheter (4) each one having a proximal end (3a, 4a) and a distal end (3b, 4b), the sheath catheter (4) being connected to its distal end (4b) to a radially deformable funnel-shaped end piece (5) that it is made of liquid-permeable material and expands in its cross section towards its distal end, and the reducing catheter (3) comprises a working head (6) and a flexible sleeve (7) connected to it, the work (6) of the reducing catheter (3) having an external diameter that is smaller than the inner diameter of the enlarged end piece for insertion in the funnel-shaped end piece (5) of the sheath catheter (4), characterized by the fact that the working head (6) of the reducing catheter (3 ) has a glove-shaped stator (8, 14, 17, 21, 25, 27, 38) and a rotor (9, 39) that is arranged centrally on it and be rotatable with reference to the stator (8, 14, 17 , 21, 25, 27, 38), of said stator (8, 14, 17, 21, 25, 27, 38) being provided over its circumference with at least one inlet opening (8a, 14a, 17a, 21a, 38a ), and said rotor (9.39) is connected to or formed in one piece with a feed screw (10.40), in which at least the side entrance opening (8a, 14a, 17a, 21a, 38a ) in the stator (8, 14, 17, 21, 25, 27, 38) is formed by at least two circular holes (15,16; 18.19; 22.23; 42,43,44) arranged axially in succession with reference to the longitudinal axis of the reducing catheter (3).
    [2]
    2. Device according to claim 1, characterized by the fact that the sheath catheter (4) has a central duct (4c),
    Petition 870190078802, of 08/14/2019, p. 32/46
    2/4 through which the reducing catheter (3) can be inserted until the working head (6) of the reducing catheter (3) in the reducing state protrudes into the region of the funnel-shaped end piece (5).
    [3]
    3. Device according to claim 1, characterized by the fact that the circumferences of the holes (15,16; 18,19; 22,23; 42,43,44) overlap, or in which the holes (18, 19 ; 22,23) are interconnected by the gap (20,24) made in the axial direction and arranged substantially centralized to the holes (18,19), the mentioned gap (24), preferably extending axially beyond the holes (22,23) towards the proximal end of the reducing catheter (3).
    [4]
    Device according to any one of claims 1 to 3, characterized by the fact that two side inlet openings approximately diametrically opposite (26) are provided on the stator (8,25) of the reducing catheter (3).
    [5]
    5. Device according to any one of claims 1 to
    4, characterized by the fact that the outside diameter of the stator (27) of the working head (6) is gradually tapered towards its free distal end.
    [6]
    6. Device according to any one of claims 1 to
    5, characterized by the fact that when the end piece (5) of the sheath catheter (4) is in the expanded state, the end piece (5) has a mesh or lattice structure and is preferably expanded as a guard -rain.
    [7]
    Device according to claim 6, characterized in that the end piece (5) of the sheath catheter (4) is radially expandable by means of an inflatable balloon, by means of a self-expanding mechanism, or by means of the reducing catheter (3).
    [8]
    8. Device according to one of claims 1 to 7, characterized in that the working head (6) of the reducing catheter
    Petition 870190078802, of 08/14/2019, p. 33/46
    3/4 (3) has an additional rotor element (41) that rotates with respect to the stator (38) and is preferably arranged on the inner face of the stator (38).
    [9]
    Device according to any one of claims 1 to 8, characterized in that the edges of the holes (15,16; 18,19; 22,23; 42,43,44) are formed as cutting edges.
    [10]
    Reducing catheter for a device according to any of claims 1 to 9, for removing and extracting removable material, such as deposits from inside the hollow body (1), in particular to remove and extract thrombi (2) and blood vessel emboli or similar, said reducing catheter comprising a working head (6) and a flexible sleeve (7) connected thereto, the working head (6) of the reducing catheter (3) having a glove-shaped stator (8, 14, 17, 21, 25, 27, 38) and a rotor (9, 39) arranged centrally to it and rotating in relation to the stator (8, 14, 17, 21, 25, 27, 38), the mentioned stator ( 8, 14, 17, 21, 25, 27, 38) being provided, over its circumference, with at least one side entrance opening (8a, 14a, 17a, 21a, 38a), and the mentioned rotor (9,39) being connected to a supply screw (10.40) or being formed in one piece, where at least one side entrance opening (8a, 14a, 17a, 21a, 38a) in the stator (8, 14, 17, 21 , 25, 27, 38) is formed by at least two circular holes (15,16; 18.19; 22.23; 42,43,44) arranged axially in succession with reference to the longitudinal axis of the reducing catheter, characterized by the fact that a slot (20, 24, 30) that runs in the axial direction and is arranged substantially central to the holes (18, 19, 22, 23, 29) is provided by which said slot (20, 24, 30) is connected with at least one of the holes (18, 19).
    [11]
    11. Reducing catheter according to claim 10, characterized by the fact that a slot (20, 24) extending in the axial direction essentially centrally to the holes (18, 19) is provided and is connected to at least one of the holes ( 18, 19).
    Petition 870190078802, of 08/14/2019, p. 34/46
    4/4
    [12]
    12. Reducing catheter according to claim 11, characterized by the fact that the holes (18, 19) are interconnected by the mentioned slot (20).
    [13]
    13. Reducing catheter according to claim 11 or 12, characterized in that the slit (24) extends axially through the holes (22, 23) towards the proximal end of the reducing catheter (3).
    [14]
    14. Reducing catheter according to one of claims 10 to
    13, characterized by the fact that the circumferences of the holes (15.16; 18.19; 22.23; 42.43.44) overlap.
    [15]
    Reducing catheter according to one of claims 10 to
    14, characterized by the fact that the outside diameter of the stator (27) of the working head (6) is gradually tapered towards its free distal end.
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    同族专利:
    公开号 | 公开日
    US8900257B2|2014-12-02|
    EP2470088A1|2012-07-04|
    EP2470088B1|2017-06-14|
    ES2639763T3|2017-10-30|
    RU2545448C2|2015-03-27|
    WO2011024124A1|2011-03-03|
    CN102481158A|2012-05-30|
    RU2012111680A|2013-10-10|
    AU2010288115B2|2014-07-10|
    ZA201201176B|2012-10-31|
    AU2010288115A1|2012-03-15|
    CA2772145C|2017-10-03|
    US20120179181A1|2012-07-12|
    BR112012004322A2|2016-03-15|
    CA2772145A1|2011-03-03|
    CH701695A1|2011-02-28|
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    法律状态:
    2018-03-27| B15K| Others concerning applications: alteration of classification|Ipc: A61B 17/3207 (2006.01), A61B 17/00 (2006.01), A61B |
    2019-01-08| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2019-07-02| B06T| Formal requirements before examination|
    2019-10-22| B09A| Decision: intention to grant|
    2019-11-05| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/08/2010, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    CH01328/09A|CH701695A1|2009-08-27|2009-08-27|Catheter with protection system for aspirating, fragmenting and out pumping of removable material from hollow bodies or vessels, in particular of the human or animal body.|
    PCT/IB2010/053816|WO2011024124A1|2009-08-27|2010-08-25|Catheter comprising a protection system for aspirating, fragmenting and extracting removable material from hollow bodies and/or vessels, in particular of the human or animal body|
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